Brazilian clubs Santos and Cruzeiro each claimed victories Wednesday in the first-leg of the Copa Libertadores round of 16.
Santos defeated Mexico's America 1-0 and Cruzeiro won 2-1 against Once Caldas of Colombia.
In two other matches on Wednesday, Mexico's Jaguares drew 1-1 with Junior of Colombia and Argentina's Estudiantes played out a scoreless draw against Cerro Porteno of Paraguay.
The second leg matches are next week, which will narrow the field to eight teams.
Pablo Ganso scored the winner for Santos in the 38th minute.
Jose Ortigoza and Wallyson scored the two goals Cruzeiro needed.
Jackson Martinez of Colombia scored in 57th minute to rally Jaguares to the draw, while Luis Paez gave Junior the lead in the 7th minute after a key pass from Jhon Viafara.
In Tuesday matches, Velez Sarsfield defeated Ecuador's Liga de Quito 3-0 and Universidad Catolica of Chile beat Brazil's Gremio 2-1.
In the final two matches of the round on Thursday, Fluminense of Brazil faces Libertad of Paraguay and Penarol of Uruguay is up against defending champion Internacional of Brazil.
