Club America and Monterrey joined Tigres on 15 points atop the Clausura table after victories Saturday.
Club America won 4-0 at Atlante, who finished with 10 men, while Monterrey were 2-1 winners at home to Puebla.
Goals from Jesus Molina Granados and Christian Benitez, the latter a penalty, put Club America 2-0 up inside 20 minutes and second-half strikes from Christian Bermudez and Oswaldo Vizcarrondo, either side of Gerardo Castillo's dismissal, rounded off the win.
Aldo De Nigris gave Monterrey victory after Puebla's Lucas Silva had cancelled out Humberto Suazo's opener.
Tigres Monterrey needed a last-minute equaliser from Elias Hernandez to salvage a 1-1 draw at Pachuca, who took the lead through Leobardo Lopez's first-half penalty.
Jaguares beat Estudiantes Tecos 1-0 thanks to Luis Rey's first-half goal while Flavio Santos struck as Atlas won by the same scoreline away to nine-man San Luis.
Isai Arredondo and substitute Moises Velasco were sent off either side of that goal.
Toluca earned a 1-1 draw at Tijuana, Ivan Alonso cancelling out Joe Corona's opener before the hosts had Juan Pablo Santiago sent off.
