After Tottenham all but ended Arsenal's title hopes, Premier League leader Chelsea is hoping Harry Redknapp's side can't make its two derby wins in four days on Saturday.
Chelsea has a four-point lead over Manchester United and a further two-point advantage over Arsenal with four games to go.
But Chelsea hasn't won a league match at White Hart Lane since August 2005 and Tottenham is still in contention for the fourth Champions League spot after beating Arsenal 2-1 on Wednesday.
"Sometimes you have a big series when you beat your opponent every time you play them and then one day it stops," Chelsea goalkeeper Petr Cech said. "I have been at Chelsea for six years and just kept my first clean sheet at home against Bolton (on Tuesday) so now it's time for our record at White Hart Lane to change too.
"Last season everything went wrong. There was a bomb alert, the game was delayed, we were kept waiting and then we started slow and lost 1-0. Even though we had chances, it was not our day. This time it's going to be different for us."
Chelsea would be even closer to a first championship crown since 2006 if United also loses at Manchester City in Saturday's early kickoff.
Morale is low at Untied after failing to win its last two league matches and being ousted from the Champions League.
"We've just got to keep going," United midfielder Ryan Giggs said. "It's been a bad 10 days or so for us - results haven't gone our way and neither has the luck, and you need both of those things to go in your favor at this time of the season.
"We've just got to bounce back from the disappointment of the last couple of weeks and we're definitely not going to give up. We're going to keep fighting until the end."
Spurs will be hoping for the opposite outcome at Eastlands as they are just a point behind fourth-place City.
"I said to the players if we could beat Arsenal we could still get fourth place," Spurs manager Harry Redknapp said. "It's still going to be hard but we're right in there and this will give us a big lift now for Chelsea on Saturday.
"It will be another difficult game against a strong team but on the back of this we will go into it with a bit of confidence. We are in great form with six wins in the last seven in the league."
Liverpool's hopes of capturing fourth spot are faint as the 18-time champions trail City by six points.
But the Reds can have a big say on the outcome of the battle against relegation as they host West Ham, which is just four points above the drop zone.
Below the Hammers, Hull and Burnley are tied on 27 points, while bottom-place Portsmouth has already been relegated.
Wigan and Bolton are level on 32 points, while Wolverhampton is a point further ahead.
While Wigan hosts Arsenal on Sunday, Bolton is at Stoke on Saturday, when Wolverhampton travels to Everton.
In the push for Europa League qualification, seventh-place Aston Villa is at Portsmouth on Sunday and Everton, which is four points behind the Birmingham side, is at Blackburn on Saturday.
