Cavaliers guard Kyrie Irving suffered a left biceps injury in the second quarter of Sunday's 102-80 loss at the Los Angeles Clippers and did not return.
Irving, who left the Staples Center with his arm in a sling, is scheduled to be examined Monday at the Cleveland Clinic.
The third-year point guard has played in 54 of the Cavs' 57 games. He missed three with a knee contusion in January.
Irving leads the Cavs in scoring (20.2 ppg) and assists (6.3 apg), and was named MVP of the All-Star Game in February. The Cavs are 1-2 without Irving this season.
He finished Sunday's game with two points on 0-for-5 shooting in 10 minutes.
Luol Deng scored 23 points to lead the Cavs, and Dion Waiters added 15 off the bench.
The Cavs (26-41) are 4.5 games behind the Atlanta Hawks for the final playoff spot in the Eastern Conference with 15 games remaining.
Blake Griffin finished with 21 points, 11 rebounds and eight assists for the Clippers (48-20), winners of 11 straight.
