Special to Outkick The Coverage from OddsShark.com
The key ACC matchup will pit Clemson quarterback Deshaun Watson against Louisville counterpart Lamar Jackson, who has emerged as the early favorite to win the Heisman. Watson was one of the preseason favorites along with Stanford Cardinal running back Christian McCaffrey.
The Tigers have won 18 straight home games according to the OddsShark College Football Database, going 10-8 against the spread during that stretch, including 1-4 in their past five.
The Cardinals have gone 10-2 SU in their last 12 games when losing the previous meeting in a series, and they are 4-0 SU and ATS in their previous four after consecutive wins. Louisville has lost the past two meetings with Clemson but covered the spread both times.
In the Big Ten, a Top-10 matchup between the Wisconsin Badgers (4-0) and the Michigan Wolverines (4-0) will also take place in Ann Arbor on Saturday. The Badgers are 7-1-1 ATS in the previous nine meetings with the Wolverines, who are listed as 10.5-point home chalk. Michigan has gone 9-2 SU in its last 11 games versus teams with winning records.
Other college football Week 5 odds and betting trends:
Tennessee (-3.5) at Georgia
Tennessee is 6-1 ATS in its last seven games against SEC opponents.
Georgia is 5-1 SU in its last six games versus Tennessee.
Texas at Oklahoma State (-3)
The visiting team is 9-0 ATS in its last nine games in this matchup.
Oklahoma State is 1-5 SU and ATS in its last six games against teams with winning records.
Oklahoma (-3.5) at TCU
Oklahoma is 0-3 ATS in its last three games versus TCU.
TCU is 7-0 SU in its last seven games after losing the previous game in a matchup.
North Carolina at Florida State (-11)
The visiting team is 5-0 ATS in its last five games in this matchup.
Florida State is 7-3 ATS in its last 10 games.
Kentucky at Alabama (-34.5)
Kentucky is 1-5 SU and ATS in its last six games against teams with winning records.
Alabama is 16-0 SU and 10-6 ATS in its last 16 games overall.
