Main Sequence repelled the late challenge of Flintshire to win the $3 million Breeders' Cup Turf by a half-length, giving the U.S. the victory in a race usually dominated by Europeans.
Ridden by John Velazquez, Main Sequence ran 1 1/2 miles in 2:24.91 and paid $14.40, $5.80 and $4.20 at 6-1 odds. The 5-year-old gelding is unbeaten in four starts since coming to the barn of Maryland-based trainer Graham Motion.
Previously, Main Sequence was based in Britain.
Britain-bred Flintshire, second in the Prix de l'Arc de Triomphe in Paris last month, returned $4.80 and $3.60. Twilight Eclipse was another 1 1/4 lengths back in third and paid $6.40 to show.
Telescope, the 8-5 favorite, finished fourth Saturday in the field of 12 at Santa Anita.
Ireland-bred Magician, the defending champion, was withdrawn earlier in the week because of lameness.
