Manning, who also had kicks of 44 and 30 yards, broke the previous record of 53 set by Dave Taggart against Northeastern on Oct. 22, 1977.
Manning's first kick, the 30-yarder, was the only score of the first half as the Wildcats (6-1, 3-1 Colonial Athletic Association) had possession for 21:04. Hofstra (4-4, 2-3) fumbled twice and threw an interception in the half.
On the possession after Manning's record-setting kick, New Hampshire forced the Pride to punt, but the snap went into the end zone for a safety and a 15-7 Wildcats' lead with 8:30 left in the game.
R.J. Toman was 14 of 21 for 148 yards and a touchdown for New Hampshire.
Hofstra's Cory Christopher was 20 of 28 for 217 yards and rushed for 56 more.