Northern Iowa (6-3, 4-2 Missouri Valley) outran its opponents 230 yards to 74, scoring all four touchdowns on the ground.
Carlos Anderson rushed for 113 yards and a touchdown for the Panthers, and Matt Strathman ran in for the team's other score.
Youngstown State (4-5, 2-4) had a solid passing game with quarterback Brandon Summers completing 22 of 35 attempts for 164 yards. Summers threw to Dominique Barnes in the second quarter for the Penguins' only touchdown.
Northern Iowa's rushing total was the most against Youngstown State this season.