Fresno State quarterback Ryan Colburn threw two touchdown passes and completed 12 of 14 pass attempts for 120 yards for the Bulldogs (2-3, 1-1 Western Athletic Conference).
Matthews entered the game averaging 148 running yards a contest, the second-most in the nation. He exceeded his average by one yard.
Hawaii (2-3, 0-2) broke its seven-quarter streak without a touchdown when Jon Medeiros recovered Greg Salas' fumble in the end zone in the fourth quarter.
Third-string quarterback Bryant Moniz, making his first career start after Greg Alexander suffered a season-ending knee injury in the Warriors' previous game, threw for 283 yards and two touchdowns.