Edwards was 19-for-28 passing for 194 yards and a 13-yard touchdown pass to Jordan Gary that gave the Mountaineers a 17-0 lead with 5:06 left in the second quarter. Edwards' 13-yard scoring run gave Appalachian State (1-2, 1-0 Southern Conference) a 7-0 advantage with 6:47 remaining in the first quarter.
Devon Moore led Appalachian State with 106 yards rushing on 17 carries.
Jason Vitaris kicked field goals of 21 and 44 yards for the Mountaineers, who held Samford (2-2, 0-1) to 86 yards passing - 4 in the first half - and just 192 yards of total offense.
Appalachian State's Ed Gainey stopped a drive with an interception on the 2-yard line.
Chris Evans led Samford with 86 yards rushing on 22 carries.