Becca Bruszewski scored 19 of her career-high 25 points in the second half, Skylar Diggins added 18 points and No. 4 Notre Dame beat DePaul 90-66 on Sunday.
With the game tied late in the first half, Diggins scored eight points during a 12-2 run, including a jumper at the buzzer to give the Irish (23-1, 10-1 Big East) a 42-32 halftime lead.
DePaul (16-10, 5-7) cut its deficit to 43-36 early in the second half on a jumper by Sam Quigley. But Bruszewski scored inside to spark a 9-2 spurt as Notre Dame went ahead 56-39 and the Irish continued to pull away.
Despite playing much of the game without Lindsay Schrader, the team's second leading scorer and leading rebounder, because of an ankle sprain, the Irish outscored the Blue Demons 50-28 in the paint. DePaul had an 41-38 edge in rebounds.
Keisha Hampton led DePaul with a career-high 28 points.