Rodolfo Salinas scored for both teams as Santos Laguna beat Unam Pumas 2-1 to stay top of the Torneo Clausura.
Christian Suarez gave Santos Laguna an 11th-minute lead, which Salinas doubled when he scored at the right end with a thunderous shot in the 65th minute.
His headed own goal 10 minutes later gave Pumas hope of a point, but they could not find an equaliser.
Atlante climbed to second place thanks to a 3-2 win away to Queretaro, as they twice came from behind to take the points.
All the goals came in the second half, with Queretaro's German Alemanno and Pablo Vitti seeing their efforts cancelled out by Osvaldo Martinez and substitute Juan Cuevas, before Martinez netted again in the 90th minute to settle the outcome.
Cruz Azul stand third following a 2-0 home success against Jaguares, earned by goals from Jair Pereira in the 55th minute and Javier Orozco six minutes later.
Monterrey were resounding 3-0 winners at home against San Luis.
Aldo De Nigris headed the opener after 30 minutes, and Cesar Delgado ran through to score the second four minutes later, before Jesus Zavala lashed home to complete the scoring in the 55th minute.
San Luis had Jehu Chiapas sent off four minutes later but kept Monterrey to three goals.
Guadalajara stay bottom of the table after five matches, having lost 2-1 at home to Morelia despite taking a first-half lead through Omar Arellano.
Miguel Sabah netted in the 57th and 83rd minutes to give Morelia the points.
On Friday, Estudiantes Tecos shared a goalless draw at home to Atlas.
