FC Porto advanced to the last 16 of the Europa League despite losing 1-0 at home to Sevilla from substitute Luis Fabiano's 71st-minute goal on Wednesday.
Porto won 2-1 in Spain last week to go through on the away goal rule.
Sevilla brought on Brazilian striker Fabiano in the 55th, taking off defender Sergio Sanchez in a bid to break the deadlock. Fabiano picked up a pass from Alvaro Negredo, muscled past Fernando and hit a low shot into the far corner.
Porto defender Alvaro Pereira was sent off for a dangerous tackle two minutes after Fabiano's strike, but then Sevilla's Alexis was shown a second yellow card to leave both teams with 10 men.
Porto had most of the chances in a lively game at the Stadium of the Dragon and appeared to be heading comfortably for the next round before Fabiano struck to set up a nervous finish.
Sevilla goalkeeper Javi Varas made a half-dozen impressive saves to deny Porto, while Falcao headed against the woodwork.
Sevilla started the encounter strongly and Frederic Kanoute, who got his team's goal in Spain, hit a curling short just wide in the third minute.
But from then on it was mostly one-way traffic as Fernando Belluschi and Alvaro Pereira tested Varas.
On Tuesday, Sergei Ignashevich scored a late equalizer to give CSKA Moscow a 1-1 draw against PAOK Thessaloniki to put the Russian club through to the last 16.
CSKA won the first leg 1-0 away, and advanced 2-1 on aggregate.
Zlatan Muslimovic put PAOK in the lead in the 67th after a mistake by CSKA substitute goalkeeper Sergei Chepchugov. But PAOK goalkeeper Dario Kresic then fouled Tomas Tosic in the area in the 80th to give CSKA a decisive penalty. Kresic stopped Brazilian striker Vagner Love's spot kick, but Ignashevich slotted in the rebound.
Thursday's matches include Liverpool against Sparta Prague, Manchester City versus Aris and Villarreal against Napoli.
