Real Betis striker Roque Santa Cruz and Estudiantes goalkeeper Justo Villar have been left out of Paraguay's squad for World Cup qualifying matches against Ecuador and Chile next week.
Santa Cruz, the former Bayern Munich and Manchester City player, has been bothered by a thigh problem, while Villar is to undergo an operation on his injured back.
Paraguay, which drew 1-1 at home against Uruguay in its opening qualifier last month, hosts Ecuador on Nov. 11 and travels to play Chile four days later.
Paraguay reached the quarterfinals of the 2010 World Cup and lost the final of the Copa America 3-0 to Uruguay earlier this year.
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Squad:
Goalkeepers: Diego Barreto (Cerro Porteno), Antony Silva (Deportes Tolima)
Defenders: Paulo Da Silva (Zaragoza), Dario Veron (UNAM Pumas), Antolin Alcaraz (Wigan Athletic), Ivan Piris (Sao Paulo), Carlos Bonet (Libertad), Richard Ortiz (Libertad), Miguel Samudio (Libertad)
Midfielders: Cristian Riveros (Kayserispor), Edgar Barreto (Palermo), Marcelo Estigarribia (Juventus), Hernan Perez, (Villarreal), Victor Caceres (Libertad), Sergio Aquino (Libertad), Julio Dos Santos (Cerro Porteno), Victor Ayala (Libertad)
Forwards: Nelson Haedo Valdez (Rubin Kazan), Oscar Cardozo (Benfica), Lucas Barrios (Borussia Dortmund), Lorenzo Melgarejo (Pacos de Ferreira), Luis Caballero (Olimpia), Pablo Zeballos (Olimpia), Edgar Benitez (Cerro Porteno)
