Fred Rutten says PSV Eindhoven will "fight until the end" as they look to get their Eredivisie title bid on track against Heracles on Sunday.
PSV could have leapfrogged Michel Preud'homme's side into top spot last weekend, but they failed to capitalise on Twente's 1-1 draw with Roda JC as they were held to a 2-2 stalemate at home by Heerenveen - and failure to beat ninth-place Heracles would dent the club's hunt for domestic silverware.
Twente are in better form than their nearest rivals, but Rutten is buoyed by the fact that PSV have an easier run-in, and is convinced that determination and sheer grit will mean his side win their 22nd Eredivisie title this year.
"I am convinced that PSV can become Dutch champions," Rutten said.
"I say that because I am sure that I know that this team will fight until the end."
Twente travel to lowly De Graafschap on Sunday and Ajax, who trail them by three points, will be looking to make it three wins in a row when they visit NEC to keep up the pressure on the leading pair.
Feyenoord will all but confirm Willem II's relegation if they win at De Kuip in Sunday's remaining fixture.
This week's Dutch League action kicks off on Friday with injury-hit FC Utrecht hoping to remain in the qualifying spots for the Europa League with a win at Heerenveen.
FC Groningen will be looking to bounce back from their 2-0 defeat to Ajax last weekend when they take on Vitesse Arnhem on Saturday.
That defeat put Pieter Huistra's team four points off an automatic qualification place for the Europa League, but club general director Hans Nijland has not written off his side's chances of finishing fourth.
He said: "When we arrive at Vitesse we will practically be assured of a play-off place but I think we can make it to fourth place, which would help us achieve our long-term objective of an automatic place in Europe."
Dirk Jan Derksen will face one of his former clubs, Roda JC, in his first match in charge of VVV Venlo on Saturday while the remaining match of the week sees NAC Breda welcome Excelsior on the same afternoon.