Mario Regueiro scored once in each half as Argentine club Lanus beat Ecuador's Emelec to move into top spot in Group 2 in the Copa Libertadores.
Bolivia's Bolivar defeated Colombia's Junior 2-1 in Group 3 in Tuesday's other match.
Lanus now leads Group 2 with seven points from four matches, two clear of Brazil's Flemengo and and three ahead of Paraguay's Olimpia.
Regueiro opened the scoring from close range in the 5th minute and, after Emelec missed two good chances, he wrapped up the result from the penalty spot in the 88th after Hugo Pavone was brought down just inside the area.
In La Paz, Bolivia, two long-range strikes helped Bolivar.
Lorgio Alvarez struck a 25-yard right-foot shot from the left side in the 31st minute and, nine minutes later, Jhasmany Campos made it 2-0 with a left-foot freekick from 30 yards.
Carlos Ruiz got one back for Junior in the 69th, finding space and beating the goalkeeper with a powerful shot from 30 yards.
Bolivar remains in second spot in Group 3 with seven points, behind Union Espanola of Chile on goal difference.
The top two teams in each group advance to the knockout round.
