The 30-year-old Russia international joined the north Londoners from Spartak Moscow in September 2008 for a reported fee of £14million.
Pavlyuchenko has only impressed in fits and starts during his time with Spurs and has been regularly linked with a move away from White Hart Lane.
Anzhi Makhachkala, QPR and Sunderland have all been mooted as potential destinations recently, although it is understood the striker could now join Lokomotiv Moscow.
Pavlyuchenko has been little more than a fringe player for Spurs this season, scoring four goals in his 14 appearances.
The striker was not named in Tottenham's 18-man squad for tonight's match with Wigan, with manager Harry Redknapp preferring to name 19-year-old Cameron Lancaster on the bench having never made a first-team appearance.
