Santos and Monterrey reached the final of the Mexico Apertura playoffs after winning their second-leg semifinals Sunday.
Santos drew 3-3 with Club America to advance on a 5-4 aggregate over two legs.
Colombian Darwin Quintero scored twice and Christian Benitez of Ecuador added the other goal.
Monterrey defeated Pumas 2-0 a few hours later to advance 2-0 on aggregate after the teams drew 0-0 in the first leg. Humberto Suazo scored in the 87th and Neri Cardozo scored three minutes later.
"It was a great game and now we'll focus on the final," Santos' Quintero said.
The first-leg final is tentatively set for Thursday at Torreon, with the second-leg on Sunday in Monterrey. Both cities are in the north of the country.