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Landon Donovan will miss the United States' match against Italy after being forced to withdraw Sunday due to illness.
Donovan will miss the chance to play together with Clint Dempsey for the first time since Jurgen Klinsmann was hired as coach last summer.
Jermaine Jones also had to pull out of US training ahead of Wednesday's game at Genoa because of a strained right calf, US Soccer said, also confirming Timmy Chandler (hamstring) and Jose Torres (hamstring) would miss Wednesday's match.
Sasha Kljestan and Brek Shea were added to the squad. Shea had been with the Under-23 team, which is set to play Mexico on Wednesday.
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FOX Wire Services contributed to this report.
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