Both Real Madrid and Barcelona will be missing key players for Saturday's match between the Spanish league leaders.
Madrid will be without Brazil playmaker Kaka, and Barcelona will be missing striker Zlatan Ibrahimovic. Kaka is still hampered by a groin injury while Ibrahimovic has failed to recover from a calf problem.
Both clubs have 77 points with eight games left to play.
Real Madrid coach Manuel Pellegrini has called on his team to show no fear as it looks to overturn a three-game losing streak against the defending champions.
"I consider Barcelona a very good team but I've never been afraid of anybody," the Chilean coach said. "A draw is always a bad result for my team. We've never speculated over a result and even less so at the Bernabeu where we still haven't lost. We've always gone out to attack our rival from the start and on this occasion it won't be any different."
If the teams draw and go on to finish the season tied on points, Barcelona would win the championship with a better head-to-head record due to a 1-0 win against Madrid in December.
Madrid is enjoying a 12-game winning streak and hasn't lost in 15 league games at the Bernabeu. But Barcelona has Lionel Messi, who is coming off a four-goal performance against Arsenal that put the team into the Champions League semifinals for the third straight year.
"The game won't be dependent on what Messi does," Pellegrini said. "Every player has an extra motivation when two such important teams meet in a match that transcends so much.
Barcelona coach Pep Guardiola wants his team to be "bold," while cautioning that last year's record 6-2 victory would be impossible to repeat.
"We have to get back to showing that we're capable of demonstrating and that we're worthy of being Spanish champions again," Guardiola said.
Guardiola, who has won all three games as coach against Madrid, will be missing left back Eric Abidal to a thigh injury, but can at least count on the return of center back Gerard Pique.
"I again want to finish the game with a very good feeling. The image we give is very important," Guardiola said. "Doing things a certain way has gotten us very far and now, more than ever, we have to do them again."
