PSV Eindhoven beat Heracles Almelo 2-0 on Sunday to share the lead in the Dutch league with FC Twente, which drew at De Graafschap 1-1.
Balazs Dzsudzsak and Marcus Berg scored for PSV.
With three rounds remaining, PSV and Twente both have 65 points with PSV enjoying a superior goal difference over the defending champion.
Willy Overtoom's missed penalty in the 75th for Heracles was decisive as PSV held on to earn a win, just three days after exiting the Europa League along with Twente.
Seeking a record 30th league crown, Ajax is third with 64 after coming from behind to beat NEC Nijmegen 2-1.
Goals from Miralem Sulejmani and Toby Alderweireld gave Ajax victory after going behind through Lasse Schone's 4th minute opener.
Former Wigan midfielder Denny Landzaat scored in the 72nd minute to give Twente the lead but Rogier Meijer headed Hugo Bargas' cross a minute before the end to equalize.
Feyenoord thrashed last-place Willem II 6-1.
On Saturday, it was: Vitesse Arnhem 2, FC Groningen 1; NAC Breda 1, Excelsior Rotterdam 2; Roda JC 5, VVV-Venlo 2; and AZ Alkmaar 3, ADO The Hague 1.
