New Bolton centre-back Tim Ream is unlikely to make his Wanderers debut.
Ream's transfer from the New York Red Bulls was confirmed last week, but the United States international has been back in his homeland sorting out passport issues related to the move and Trotters boss Owen Coyle says it will be "tight" for him to get back in time for the Gunners match.
Fellow defender Tyrone Mears, a summer signing from Burnley, could make his bow for Bolton and goalkeeper Jussi Jaaskelainen may return to the team after both were on the bench for Saturday's 2-1 FA Cup fourth-round victory over Swansea having recovered from a broken leg and thigh problem respectively.
Arsenal will have Swiss defender Johan Djourou (calf) available for the game.
Full-back Bacary Sagna returned from four months out with a broken ankle with a late substitute appearance in the 3-2 FA Cup win over Aston Villa, but may be rested. Thierry Henry and Mikel Arteta (both calf) are available.
Full-back Kieran Gibbs (groin) has returned to normal training, but Carl Jenkinson (back), Andre Santos (ankle) and midfielder Abou Diaby (hamstring) are still out while strikers Marouane Chamakh and Gervinho are away at the African Nations Cup and midfielder Jack Wilshere suffered a setback in his rehabilitation from an ankle injury.
Bolton (from): Bogdan, Jaaskelainen, Wheater, Boyata, Knight, Mears, Eagles, Robinson, Muamba, Petrov, K Davies, Klasnic, Tuncay, M Davies, Pratley, Ngog, Blake, Reo-Coker, Steinsson, Ricketts, Riley, O'Halloran.
Arsenal (from): Szczesny, Vermaelen, Mertesacker, Djourou, Koscielny, Walcott, Song, Ramsey, Oxlade-Chamberlain, Rosicky, van Persie, Almunia, Park, Yennaris, Squillaci, Benayoun, Miquel, Arshavin, Henry, Arteta, Coquelin.
