Arsenal midfielder Alex Oxlade-Chamberlain is set for around four weeks on the sidelines with a hamstring strain.
The 21-year-old limped off in Monday's 2-1 FA Cup quarter-final win at Manchester United and will now miss England's Euro 2016 qualifier against Lithuania on March 27.
England also face Italy in a friendly match in Turin on March 31 and manager Roy Hodgson may use the double-header to ease Oxlade-Chamberlain's club-mate Jack Wilshere back into international action, with the midfielder expected to return from minor ankle surgery next week.
Oxlade-Chamberlain will also be unable to aid Arsenal in their bid to turn around a 3-1 deficit when they travel to face Monaco in their Champions League last-16 second-leg tie and is a major doubt for next month's potentially crucial Premier League clash with Liverpool.
