NFL Week 5 Betting Picks

Updated Mar. 4, 2020 11:50 p.m. ET

foxsports

Special to Outkick The Coverage from OddsShark.com

The most notable story is the return of Tom Brady from his four-game suspension for the New England Patriots, who are coming off their first loss. Then there's unbeaten rookie quarterback Carson Wentz and the Philadelphia Eagles as they visit the Detroit Lions off their bye week. Find out if the Patriots can cover as double-digit chalk and if the Eagles are the real deal below.

Patriots (-10.5) at Browns (Sun, 1 p.m. ET) - Matchup Report

We all know how well Brady plays when motivated, so expect the public to be all over New England in this matchup. But the Cleveland Browns are the worst team in football with a rookie quarterback making his first home start in Cody Kessler, and they are just 2-10 against the spread in their last 12 games as underdogs, according to the OddsShark NFL Database. You know what to do, back Brady and Bill Belichick in a massive revenge spot versus the NFL.

Eagles (-3) at Lions (Sun, 1 p.m. ET) - Matchup Report

Is Philadelphia a pretender or a contender? It's still too early to tell, but this game will show us a lot, especially since the Lions have their backs up against the wall following a three-game skid. Detroit is facing a must-win situation here and has gone 3-1 ATS in the past four meetings. Look for the Lions to get back on track with a win and end the unbeaten streak for the Eagles.

Bills at Rams (-1) (Sun, at 4:25 p.m. ET) - Matchup Reportbra

The Los Angeles Rams are another team that has surpassed expectations in winning three straight games since getting blanked by the San Francisco 49ers in their season opener. However, the Buffalo Bills just shut out the mighty Pats behind a strong defensive effort, and they have gone 5-2 straight up and ATS in the previous seven head-to-head matchups with the Rams. Los Angeles has also gone 3-7 SU in its last 10 after winning as a dog, so take Buffalo.