Bernardo Anor's early goal helped the Columbus Crew defeat Portland 1-0 on Sunday to end the Timbers' 15-game unbeaten streak.
Portland (7-2-9) had gone 7-0-8 since March 9 while the Crew (6-8-5) ended a three-game losing streak.
Anor scored in the fourth minute off a restart from Federico Higuain for the second straight match with a snap header from 6 yards to the inside of the left post.
But Higuain failed to increase the lead seven minutes later as he missed his second penalty kick in six attempts this season by shooting the ball left of the net.
Aaron Schoenfeld drew the penalty and a red card to Pa-Modou Kah in the 11th when the defender stuck his right foot into the face of Schoenfeld.