The Bulldogs (8-1, 6-0 Mid-Eastern Athletic conference), led 22-6 at halftime on two field goals by Blake Erickson, two touchdown passes by Malcolm Long and a safety.
William Ford finished with 108 yards on 16 carries for South Carolina State, which outgained the Bison (2-7, 0-6) 180-62 on the ground.
Terrance Smith gave the Bulldogs a 10-0 lead late in the first quarter on a 28-yard pass from Long. Massey then caught a 14-yard TD pass from Long for a 17-3 advantage early in the second.
Long finished with 180 yards on 21-of-33 passing for the Bulldogs, who need one more win for their second-straight conference title.
Howard's Floyd Haigler was 14 of 29 with 159 yards, a touchdown and three interceptions.