The absence of first-choice center backs Terry and Kurt Zouma paves the way for Gary Cahill and Branislav Ivanovic to partner in the heart of the back four. Ivanovic slid over from his usual berth at right back after Terry departed against Newcastle at the weekend.
Miazga and Jake Clarke-Salter are the options in reserve, but their lack of experience at the top level likely leaves them as emergency alternatives in the event of further setbacks. Miazga is likely to feature on the bench as he awaits his first appearance since signing from New York Red Bulls last month.
Recent loan signing Alexandre Pato missed out on a place in this squad as he continues to work his way toward full fitness, while Nemanja Matic is suspended for the tie.