Seattle came away with a 26-24 home victory back on Oct. 16, but things could be very different this time around.
Here are seven things that have changed since that Week 6 matchup.
Thomas Rawls is in at running back
In Seattle's Week 6 victory, Christine Michael was the leading rusher for the Seahawks, carrying the ball 18 times for 64 yards and two TDs while Rawls was sidelined due to injury.
Once he was healthy, Seattle waived Michael (who caught on with the Packers), and Rawls was dominant in the Wild Card win over the Lions, rushing for 161 yards and a touchdown.
Earl Thomas is out for the season
Seahawks safety Earl Thomas had a key interception late in the Week 6 matchup with the Falcons, but was lost for the season with a broken leg injury in a win over the Panthers on Dec. 4.
Seattle's defense looked just fine without him against Matthew Stafford, but facing Matt Ryan and the Falcons in Atlanta will be a much tougher test.
Vic Beasley has become a monster
The Falcons selected Vic Beasley with the eighth overall pick in the 2015 draft, but he didn't pay immediate dividends while tallying just four sacks during his rookie season.
In his second year in the league, however, Beasley has turned into one of the game's dominant pass rushers, and finished the regular season as the NFL's sack leader with 15.5 on the season. He was held without a sack in four of Atlanta's first six games of the year (including that Week 6 loss), but has been on a tear ever since.
Tyler Lockett is out for the season
Lockett suffered a broken leg injury in Seattle's Dec. 24 loss to the Cardinals. A versatile wide receiver and kick returner, Lockett finished 2016 with 1,560 all-purpose yards to go along with one rushing and one receiving touchdown.
Rookies Deion Jones and Keanu Neal have boosted the Falcons defense
The Falcons have improved greatly on the defensive side of the ball in the second half of the season, and in addition to the play of Beasley, rookies Deion Jones and Keanu Neal have been the ones making the biggest impact.
Atlanta's top two draft picks of 2016 lead all rookies in tackles, and the Falcons allowed 19 points or less in four of their last six games of the regular season.
Seattle's offensive line has found its way
When Thomas Rawls rushed for 161 yards and a touchdown in Seattle's Wild Card win over the Lions, he was often running through huge holes like the one you see pictured above. That's a testament to the offensive line, and if they've truly figured things out, that could help the Seahawks control the clock a little and keep Matt Ryan and Atlanta's high-powered offense off the field more than usual.