The Dolphins and Ryan Tannehill had a rough go of it in Cincinnati, and dropped to 1-3 on the season after their 22-7 loss.
Here are the 10 best things to look for when Week 4 continues on Sunday, including Cam Newton and the Panthers heading to Atlanta while trying to avoid a similar start.
Best chance for an upset
Raiders over Ravens: The Ravens may be 3-0 and playing this game at home, but their wins have all been close, and have come against the Bills, Browns and Jaguars, who aren't exactly the league's elite. Derek Carr and the Raiders come in 2-1 with a top-10 offense, and very well could come away with their third road win of the season.
Cary Edmondson-USA TODAY SportsCary Edmondson
Best survivor pool pick
Cardinals over Rams: It's true that Arizona is off to a disappointing 1-2 start, but this week they're at home, where the Cardinals were able to score 40 points in their only win thus far. The Rams don't have the firepower to hang around, and they come into the contest with only a middle-of-the-pack defense.
Getty ImagesChristian Petersen
Best individual matchup
Rex Ryan trying to match wits with Bill Belichick is always a good time. Ryan posed as a reporter on a conference call to try to get information on the Patriots' quarterback situation, while Belichick predictably wanted no part of any of Ryan's nonsense.
The Bills got on track with a nice win over the Cardinals last week, but beating the Patriots at Foxboro, no matter whom New England starts at QB, is a fairly tall task.
Best bad game
The NFL insists on continuing to send the Jaguars to London for some reason, which seems like an odd way to try to grow the game. Blake Bortles and Jacksonville are off to an 0-3 start, and facing a 1-2 Colts team that's given up an average of 31.7 points per game, which is third-worst in the league behind only New Orleans and Tampa Bay.
But the fact that this game is in London means football is on at 9:30 a.m. Eastern, and despite the horrible matchup, that fact alone means plenty of you will watch.
Getty ImagesRob Foldy
Best fantasy option
DeMarco Murray ran for 114 yards and a touchdown in last week's loss to the Raiders, and he's averaged more than 7 yards per carry in each of his past two games. Tennessee also uses him in the passing game, as he's had at least five receptions in all three games this season.
Combine all that with the fact that the Texans' run defense was ranked 26th in the league even before J.J. Watt was ruled out for the season, and Murray could be in for a big day in Houston on Sunday.
Best chance for a shootout
Saints-Chargers: San Diego has scored 65 points combined over the past two weeks, while Drew Brees and New Orleans have scored at least 32 points in two of its three contests.
The Saints also are allowing opposing quarterbacks to complete 69.7 percent of their passes, and when factoring all of that in, the over/under of 53.5 set by oddsmakers feels awfully low for this one.
Best bet against the spread
Detroit's Marvin Jones torched the Packers for 205 receiving yards last week, so it's scary to think what he might be able to do against a depleted Bears secondary. He's technically listed as questionable, but reporters saw him practicing with the Lions on Friday and he appeared to be just fine.
Jay Cutler is listed as doubtful and Alshon Jeffrey is questionable. Add it all up and taking a 1-2 Detroit team on the road while laying three points doesn't scare us at all.
Best chance for a low-scoring contest
Seahawks-Jets: Richard Sherman and Seattle have been winning with their league-leading defense, and have allowed just 12.3 points per game while getting off to a 2-1 start.
The Jets, meanwhile, have Ryan Fitzpatrick at quarterback, who just happened to throw six interceptions in last week's loss to the Chiefs. New York's leading receiver Eric Decker is out with a shoulder injury, and Russell Wilson vows to be playing, despite dealing with a knee injury. The oddsmakers set the over/under at 40.5, and we'd be surprised if the final total ever got that high.
Getty ImagesJeff Gross
Best late game
Cowboys-49ers: Dallas is much better than San Francisco on paper, and that's especially true with Dak Prescott at the quarterback position. But oddsmakers have the Cowboys as only a three-point favorite on the road for a reason.
The Cowboys very well could be without Dez Bryant, who is somehow questionable despite being diagnosed with a hairline knee fracture. While his production has been below average, he's a threat on the field that the defense must respect.
The Niners are coming off of consecutive blowout losses on the road, but the Cowboys' 21st-ranked defense isn't exactly comparable to that of the Seahawks. This one should be closer than expected.
Panthers-Falcons: Carolina is off to a 1-2 start, which normally might not be too much cause for concern. But because of that record, heading on the road to face the 2-1 Falcons now becomes way more important than any Week 4 game should.
A loss would put Atlanta in a strong position to win the division, and a 1-3 start would make things tough for the defending NFC champs. These implications should make Cam Newton and Carolina desperate enough to give the Falcons all they can handle, which should make for compelling television.