Anna Martin scored 21 points to lead five players in double figures for No. 21 DePaul in 93-67 victory over Southern Illinois on Thursday night.
The win was the ninth in 10 games for DePaul (12-2) and 26th straight at McGrath-Phillips Arena.
Jasmine Penny scored 15 points, Brittany Hrynko had 14, Kelsey Reynolds had 12, and Katherine Harry added 11 points and 10 rebounds for the Blue Demons, who lead the series 9-3.
Teri Oliver scored 25 points and Cartaesha Macklin added 18 for Southern Illinois (3-7), which has lost five of its last six.
DePaul never trailed, opening a 13-2 lead just 2:53 into the game and taking a 51-18 advantage at halftime. Their biggest lead was at 62-26 with 17:23 remaining in the game.
The Blue Demons held a 40-34 rebounding edge and outscored the Salukis in the paint (44-14), off turnovers (33-16) and on second chances (15-5).
