Danielle Robinson scored 16 points to help No. 12 Oklahoma beat Colorado 65-55 on Saturday.
It was the Sooners' eighth straight victory over the Buffaloes, who have lost their last 19 games against ranked opponents.
Oklahoma (17-6, 7-3 Big 12) scored the first 11 points and led 17-2 with 14:21 left in the first half. Colorado twice rallied to within five points, including 23-18. Oklahoma answered with a 17-3 run and never looked back.
The Sooners saw their lead expand to 25 in the second half.
Oklahoma, which has lost all six games to ranked opponents, will host top-ranked Connecticut on Monday night.
Brittany Spears scored 28 points and grabbed nine rebounds to lead Colorado (12-11, 2-8), which has lost six straight.