Valencia, Porto score first leg victories in Europa League
Jackson Martinez scored the only goal in the 57th minute as hosts Porto claimed a 1-0 first-leg advantage over Napoli.
AZ Alkmaar put themselves in the driving seat in their tie against Anzhi Makhachkala, nicking a 1-0 lead in Holland thanks to a first-half penalty from Aron Johansson.
Basel ended Salzburg's 14-game winning streak in all competitions as they played out a goalless draw in the first leg at St Jakob Park.
Lyon will be expected to reach the last eight following a 4-1 win over Plzen.
Tomas Horava took advantage of some poor defending from the Ligue 1 side to claim an early lead before the score was levelled by Gueida Fofana 10 minutes later.
Alexandre Lacazette gave Lyon the lead early in the second half before Arnold Mvuemba and Fofana wrapped up the win.
Real Betis stunned city rivals Sevilla with a 2-0 win despite being outplayed for much of the derby.
Sevilla had won their previous four games in all competitions and were six unbeaten, and they dominated Thursday night's game.
Yet they somehow came away facing an imposing second-leg test next week after Leo Baptistao's first half header and Salva Sevilla's strike gave Betis victory.