Copa América

Top Billing in South America: Argentina vs. Uruguay

Updated Mar. 4, 2020 4:29 p.m. ET

RIO DE JANEIRO (AP) Lionel Messi is back for Argentina. And Luis Suarez is expected to return for Uruguay.

The two Barcelona teammates should be the focus on Thursday in South America's most high-profile World Cup qualifier.

With four rounds of qualifying remaining, Brazil has already advanced to Russia and leads the group with 33 points. The five-time World Cup winners are followed by Colombia (24), Uruguay (23), Chile (23), Argentina (22) and Ecuador (20). Peru and Paraguay have 18 points, and little chance to advance. Bolivia and Venezuela have been eliminated.

In addition to Brazil, three more teams will claim the remaining automatic berths, and one more South American team could also reach Russia in a playoff.

A look at the key games:

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URUGUAY-ARGENTINA

Messi is back from a one-game ban for insulting a match official. It was originally four matches, but the Argentine soccer association appealed successfully.

That's good news for coach Jorge Sampaoli, who will be on the bench for his first official game in charge. Without Messi, Argentina lost to Bolivia 2-0 in its last qualifier in March.

Uruguay coach Oscar Tabarez also needs Suarez. He has a right-knee injury, which Tabarez said will be evaluated in the run-up to the match.

With or without Suarez, Tabarez knows ''it will be a very, very difficult match.''

Sampaoli replaced Edgardo Bauza in early June and has coached friendly wins over Brazil and Singapore. Sampaoli has left Juventus striker Gonzalo Higuain out of the side, going instead with Paulo Dybala, who is seen as Messi's heir on the national team.

Tabarez is remaking the Uruguay side, which has been about the same since finishing fourth in the 2010 World Cup and the 2011 Copa America. New faces include Federico Valverde, Mauricio Lemos and Gaston Pereiro.

''It's not just another game coming up,'' Uruguay defender Diego Godin said. ''It's a classic, and we know who we're playing.''

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VENEZUELA-COLOMBIA

Colombia attacking midfielder James Rodriguez is out with a right thigh injury. His new club, Bayern Munich, has allowed him to travel, under the condition that he doesn't play. He could be available for the Sept. 5 qualifier against Brazil.

The match takes place in San Cristobal, Venezuela, in the midst of the South American country's deepening social and economic crisis.

Argentina-born coach Jose Pekerman should be able to get by without Rodriguez. Venezuela has only six points from 14 matches.

''Venezuela playing Colombia is always played as if your life depends on it,'' Colombia winger Juan Guillermo Cuadrado said.

Colombia will rely on Radamel Falcao, who has scored seven goals for French club Monaco in only four games.

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BRAZIL-ECUADOR

Brazil has advanced, winning eight straight qualifiers under coach Tite.

Tite will have Neymar, fresh off his record-breaking transfer to Paris Saint-Germain. The player most watched will be winger Philippe Coutinho, who has yet to play a minute with Liverpool. The English club says Coutinho has been out with a back injury. Meanwhile, Coutinho has been linked in a move to Barcelona to replace Neymar.

Ecuador needs a victory in the match in the southern city of Porto Alegre to stay in the race.

''It's a tough challenge,'' Ecuador coach Gustavo Quinteros said. ''But Ecuador has shown when it plays well, it can beat anybody.''

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CHILE-PARAGUAY

Chile's hopes in Santiago against Paraguay probably ride with Alexis Sanchez, who played his first minutes of the season in Arsenal's 4-0 loss to Liverpool. Sanchez missed the first two matches with an injury.

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PERU-BOLIVIA

Peru and Bolivia play the other match with neither team going anywhere. Peru will be without captain and top scorer Paolo Guerrero, who is suspended. He is eligible for the next match against Ecuador.

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Zuniga reported from New York.