Liverpool manager Rafael Benitez looks set to be without Fabio Aurelio for two to three weeks after the defender picked up a thigh injury.
Aurelio was forced off midway through the first half of Sunday's victory over Blackburn after straining quadriceps in his right leg and he now looks set for another spell on the sidelines.
Aurelio has not had the best luck with injuries, having missed the start of the season after sustaining a freak knee problem in a kickabout with his children during the summer.
Since then he has struggled with a few niggling injuries but appeared to be ready for a longer run in the team before this latest setback.
"It's not good news and we think he is going to be out for maybe another two or three weeks - Fabio has had really bad luck," said Benitez.
"It all began at the start of the season, when he suffered the injury during the summer with his family, and it's like there has been something every month since then.
"It is a shame because he is a top footballer and a really nice person but him being out leaves us with a problem because we wanted to play him, so we could give Insua a rest.
"Emiliano (Insua) is a good young player and has benefited from being involved in so many games but he has been playing a lot recently.
"We needed Fabio so he could help the team and also help Insua. His injury is bad news for both of them."
With Glen Johnson on the verge of a first-team comeback it seemed Benitez's injury worries were over until Martin Skrtel broke a foot in last week's Europa League tie in Romania and Daniel Agger injured a knee against Blackburn.
There is, at least, some encouraging news concerning the Denmark centre-back.
"We will continue to watch Daniel," Benitez told the Liverpool Echo. "We are glad that it is nothing serious but whether he is available for Wigan (on Monday) depends on his progression in the next few days."
