Struggling Lille head into their crucial Ligue 1 showdown with Lyon on Sunday with striker Dimitri Payet warning: "Defeat is forbidden."
Lille's patchy start to the season took a significant turn for the worse on Wednesday when they were beaten 3-1 in the Champions League by BATE Borisov.
The champions of Belarus had never previously won a group stage match in the competition.
Lille have won just once in Ligue 1 so far this season and last weekend they threw away two points when Troyes snatched a draw with an 88th-minute equaliser.
League leaders Marseille are already nine points ahead with Lyon seven points better off than Rudi Garcia's men.
"Defeat is forbidden," Payet said. "If we manage to start the game well and play like we did in the second period against BATE, then maybe we will have a pleasant surprise."
Lyon, in contrast, are in buoyant mood after beating Sparta Prague in the Europa League on Thursday, courtesy of second-half goals from Bafetimbi Gomis and Lisandro Lopez.
"I was really impressed by my team," said manager Remi Garde.
"I liked the intensity they showed when on the ball and the intelligence of my players.
"We created lots of chances against a team who were not just aggressive but were also well organised in defence.
"We didn't take enough of our chances, and that prevented us from being more relaxed at the end of the game but what I prefer to take away from the game is the control and commitment we showed."
Lyon will be without defender Mouhamadou Dabo, who suffered a blow to the head last week, and playmaker Yoann Gourcuff.
Lille's Marvin Martin is struggling with an adductor injury suffered against BATE, while Salomon Kalou is suspended.