Shinji Kagawa, Yasuhito Endo and Keisuke Honda scored second-half goals as Japan beat an experimental Ghana side 3-1 in a friendly on Tuesday.
Asamoah Gyan and Michael Essien were among 10 top players dropped from the Ghana squad for the match at Yokohama International Stadium.
Kevin-Prince Boateng also didn't make the trip for Ghana, which beat Zambia 2-1 on Friday to secure one of seven remaining places in Africa's final playoffs for the World Cup.
Frank Acheampong put Ghana on the scoresheet in the 24th minute on a left-footed effort that deflected off a defender and beat Japan goalkeeper Eiji Kawashima.
Midfielder Kagawa equalized in the 50th minute and Endo and Honda widened the lead for Japan, which has already qualified for the World Cup.
