Holders Inter paired with Bayern
Holders Inter Milan have been handed a Champions League last-16 tie with Bayern Munich in a repeat of last season's final.
Inter president Massimo Moratti said: "It's an interesting draw.
"For them it will be a way to avenge that defeat.
"We have faced Bayern many times and it is an historic showdown but it's early days to make a judgement.
"We will have to wait and see in which conditions physically and psychologically both teams arrive to the games."
Benitez added: "I think it will be interesting for the fans and for the stars that experienced the final in Madrid.
"Bayern Munich are a fantastic team, led by a great coach."
Meanwhile, Mourinho's Real Madrid will have revenge on their minds as they face Lyon. Madrid were knocked out at the last 16 stage for the sixth successive time last year after losing 2-1 on aggregate to the French outfit.
Madrid sporting director Miguel Pardeza said on his club's website: "We still have last year's tie fresh in our minds and I hope this year we are the team to go through.
"The team is ready and we are now more familiar with Lyon."
Lyon president Jean Michel Aulas, whose side reached the semi-finals for the first time last season before falling to Bayern Munich, said: "It's hard to pick a favourite. Madrid are better than last year and it makes for an interesting match. It will be intense and hard for them."
Lyon are also set to come against their former striker Karim Benzema again.
Aulas added: "Benzema is a much-loved player in Lyon and I hope it's an important match for him."
In the two other games not involving the four English sides, Valencia will play Schalke and Roma have to overcome Shakhtar Donetsk.
Roma coach Claudio Ranieri expects his team's tie to be a true spectacle.
"I know other clubs would have been happy to have been drawn against Shakhtar," said Ranieri. "But I had no preference.
"The important thing for me is that my team goes into those games in the best possible condition."
Shakhtar claimed 15 points of a possible 18 to finish ahead of Arsenal in the group stages and Ranieri knows his team will be tested by the Ukrainians.
"It's going to be a beautiful tie," said Ranieri. "They have won five of their six games and are a team that has great individual talent.
"They are very fast in counter-attacks and it will be a big test for us."
Roma v Shakhtar Donetsk, AC Milan v Tottenham, Valencia v Schalke, Inter Milan v Bayern Munich, Lyon v Real Madrid, Arsenal v Barcelona, Marseille v Manchester United, Copenhagen v Chelsea.
First legs will take place on February 15-16 & 22-23, second legs on March 8-9 & 15-16.