Hamburg picked up their first win of the season and brought an end to Borussia Dortmund's 31-game unbeaten streak with a 3-2 victory at the HSV Arena.
Hamburg took the lead in the second minute through Heung Min Son - Rafael van der Vaart the provider on his second home debut for the club - and they remained in front until the start of the second half when Ivan Perisic brought the defending champions level.
Ivo Ilicevic restored Hamburg's advantage in the 55th minute and Son's second of the game gave them a two-goal cushion, which they were only able to hold for 60 seconds before Perisic brought the Westphalians back into the game.
However, Dortmund could not find an equalizer, despite spending the last 20 minutes inside the Hamburg half, and had to taste defeat for the first time in almost a year.
Wolfsburg failed to win in front of their own fans once again as they were held 1-1 by a gritty Greuther Furth.
Emanuel Pogatetz gifted the visitors the lead with an own goal in the 27th minute, but Ivica Olic spared the Wolves' blushes three minutes before half-time.
Mainz picked up their first league win of the season to leave opponents Augsburg in their wake and struggling towards the bottom of the table.
Andreas Ivanschitz gave Thomas Tuchel's side the lead in the 10th minute and an Adam Szalai goal a quarter of an hour later was enough to earn them all three points.
The day's other game between Fortuna Dusseldorf and Freiburg finished 0-0.
In Sunday's action, Andre Schurrle missed a penalty as Bayer Leverkusen were held to a 1-1 draw by Borussia Monchengladbach at the BayArena.
In the battle of two of Germany's Europa League participants, both of whom drew 0-0 last Thursday, Leverkusen did everything but score more than their opponents, who collapsed after taking an early lead through Patrick Hermann.
Michal Kadlec soon levelled for Leverkusen but they were unable to find a winner in almost 80 minutes of a one-sided game, including Schurrle's penalty miss in the 70th minute.
Hoffenheim picked up their first win of the 2012/13 Bundesliga campaign to end Hannover's own unbeaten start with a 3-1 victory.
An own goal from Mathieu Delpierre compounded what has been a start of the season to forget for Hoffenheim, but Fabian Johnson replied immediately at the Rhein-Neckar Arena.
Late goals from Sejad Salihovic and Daniel Williams then gave Hoffenheim some long-awaited joy as they moved off the foot of the table with their first three points of the season.
Werder Bremen and Stuttgart played out a thrilling 2-2 draw at the Weser Stadion as both sides ended the game with 10 men.
Kevin de Bruyne and Zlatko Junuzovic established a two-goal advantage for the home team before half-time, but Stuttgart never gave up and recovered with goals from Martin Harnik and Cacau.
Harnik was then shown a second yellow card, and was soon followed down the tunnel by Assani Lukimya after he was given a red card late on.
