Marco Reus faces a longer-than-expected three months out after picking up a foot injury in Germany's World Cup warm-up match against Armenia on Friday.
The Borussia Dortmund midfielder was carried off the field in tears and was officially ruled out of the Brazil showpiece on Saturday after early scans confirmed a partial ligament tear in his left ankle.
Without Reus, Joachim Lowe's Germany are priced at 6/1 to win the tournament.
It was hoped that he would be able to return in time for the start of the new Bundesliga season in August, but further tests at Dortmund's Knappschafts hospital with club doctor Markus Braun have ruled that out.
"The tests revealed that, in addition to his ankle injury, Reus also suffered damage to the heel bone with an expected recovery time of about three months," the club said on their official website.
