Although Guardiola committed himself to the Camp Nou outfit for another season earlier this year, there has still been speculation over his future.
It is thought the club's highly-successful tactician could take a break from the game after the Wembley final, although he could also become a target for managerless Chelsea.
Cruyff, who still acts as an advisor for the Catalan giants, believes Guardiola could leave the club regardless of the result of Saturday's mouth-watering clash at Wembley.
"Guardiola has worked very hard over the last few years and it wouldn't surprise me if he left independently of Saturday's result," said Cruyff.
"If he left, it would only be because it is very difficult to withstand certain pressures in the long term."
Guardiola, meanwhile, knows Barcelona could be caused problems by Manchester United's rising star Javier Hernandez.
Hernandez has been a revelation at Old Trafford since joining from Chivas for £7million last summer, scoring 19 goals in all competitions for Sir Alex Ferguson's men to help them to the Premier League title and the UEFA Champions League final.
Barca will meet United in that decider at Wembley, and coach Guardiola is aware of the threat posed by the young Mexican.
The Spaniard said: "He's a huge surprise, he's amazing.
"He's amazing when arriving in the area. He has incredible movement without the ball. Manchester United have bought an enormous young talent.
"I am convinced that he will be an important player for the next few years at United."
Hernandez is determined to crown a dream debut season at United by complimenting their league success with the European trophy.
He said in the Daily Star: "I wanted to make the people here, the board, who spent all this money on me, sure that it was a good thing.
"Now I want to help my team to get another trophy.
"We have the 19th title but hopefully, come Saturday, the Champions League as well.
"We want to play like we have done for the whole season."