Uruguayan side Penarol took a crucial step towards the Copa Libertadores semi-finals by beating Chile's Universidad Catolica 2-0 at home in the first leg of its quarterfinal.
Juan-Manuel Olivera put Diego Aguirre's side ahead in the 36th minute as he took advantage of a mistake from Catolica goalkeeper Paulo Garces.
Alejandro Martinuccio sealed the win with a second goal in injury-time.
Penarol midfielder Nicolas Fleitas told Fox Sports: "We just won the first half. Now we'll play the second (next Thursday).
"We have to do our very best in Chile to progress. They play very good football. Maybe we were lucky with the goals we scored, but the lead is very important to go to Chile.''
Santos - the only Brazilian team still in the championship - claimed a 1-0 away at 10-man Once Caldas.
Neymar set up Alan Patrick for the only goal of the game two minutes before half-time at the Estadio Palogrande in Manizales.
Defender Elkin Calle was sent off in the second half after he fouled Nilmar, who was unable to continue.