Charles N'Zogbia may return to the Aston Villa side.
The winger has been out with a heel injury but could play some part at Villa Park.
James Collins (calf) and Marc Albrighton (thigh) will both miss the fixture while Chris Herd is a long-term absentee with an ankle ligament problem.
New signing Djibril Cisse could make his QPR debut.
The 30-year-old completed his move to Loftus Road from Lazio on Tuesday and is eligible to feature at Villa Park, subject to international clearance being received at least one hour before kick-off. Fellow strikers Jay Bothroyd (groin) and DJ Campbell (hamstring) are out, while Heidar Helguson (groin) is a major doubt.
Akos Buzsaky (ankle) and Danny Gabbidon (hip) are also doubts, while Armand Traore and Adel Taarabt are on international duty. Taye Taiwo and Nedum Onuoha could also make their QPR debuts.
Aston Villa (from): Given, Guzan, Agbonlahor, Albrighton, Bannan, Clark, Collins, Cuellar, Dunne, Ireland, Marshall, Petrov, Warnock, N'Zogbia, Hutton, Weimann, Johnson, Burke, Bent, Heskey, Keane, Stevens, Baker, Lichaj, Gardner.
QPR (from): Kenny, Cerny, Murphy, Gabbidon, Onuoha, Ferdinand, Taiwo, Hall, Hill, Young, Derry, Barton, Buzsaky, Smith, Mackie, Helguson, Wright-Phillips, Hulse, Macheda, Cisse.
