Reigning champion America will play for its twelfth league title and a chance to become Mexico's most successful club after booking a spot against Leon in the Apertura tournament final.
America defeated Toluca 2-0 to take a 3-2 aggregate victory Sunday, while Leon drew 2-2 against Santos Laguna to win 5-3 over the two legs.
Mexico City team America is currently tied with Guadalajara rival Chivas on eleven league titles, while Leon, which was promoted to the first division in 2012, hasn't won a championship since 1992.
The first leg of the final is scheduled to be played on Thursday in Leon, with the return leg in Estadio Azteca next Sunday.
Colombian Aquivaldo Mosquera headed in America's first in the 13th minute before Jesus Molina sealed the win with a header six minutes from the final whistle.
''We have to work hard and understand that there are two games left, but we are in the only situation in which we can aspire to winning consecutive titles,'' America coach Miguel Herrera said.
Oribe Peralta opened the scoring for Santos Laguna in the 51st but Argentine Mauro Boselli placed a delicately lofted shot at the near post to equalize five minutes later, after a left wing cross from Matias Britos.
Carlos Pena rounded the `keeper and tapped in to hand Leon the lead in the 89th, before Juan Pablo Rodriguez leveled from the penalty spot with the last touch of the game.
