Andre Drummond had 15 points and eight rebounds and Detroit rallied late, taking its first lead since the final quarter at 104-103 with 1:08 left. Cleveland led 83-64 in the third quarter.
Bruce Brown, Derrick Rose and Reggie Jackson added 15 points each for Detroit (2-1).
Collin Sexton scored 24 points and made 3 of 5 from 3-point range for Cleveland (1-1). Tristan Thompson added 15 points and eight rebounds.
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