A.J. Guyton finished with four catches for 113 yards and a touchdown; he also threw a touchdown pass. Rob Calabrese threw for 71 yards and two touchdowns on 3-of-4 passing.
Ronnie Weaver finished with 58 yards and a score on five carries to lead the Knights (4-3, 2-2 C-USA) back into the Conference USA East race and give them their 50th road win in school history.
Hodges found Guyton for a 76-yard touchdown pass 20 seconds into the game, and Central Florida never looked back. Hodges ran for a 1-yard touchdown with 3:27 left in the first quarter to cap a 14-play, 87-yard drive and make it 14-0.
Weaver tacked on a 27-yard touchdown run with 2:02 left in the first before Guyton found Kamar Aiken for a 36-yard scoring strike on a halfback pass to extend the lead to 28-0 at the half.
After UCF extended the lead to 42-0 with Josh Robinson's interception return for a touchdown and Calabrese's touchdown pass to Jamar Newsome, Rice (0-8, 0-4) got on the board with a 1-yard touchdown run by Charles Ross.
Nick Fanuzzi finished 17 of 26 for 116 yards, and Ross had 63 yards and a touchdown on seven carries to lead Rice on the ground. Toren Dixon caught six passes for 54 yards.