Brown was strapped onto a backboard and carted off the field after lying on the ground for several minutes following an 8-yard catch that set up a field goal. South Carolina fans chanted "Let's Go Moe" as he was taken into the tunnel, making a thumbs-up gesture.
South Carolina officials said he was diagnosed with a concussion and would return to Columbia with the team.
The senior is the Gamecocks' leading receiver and came in needing 51 yards to become the 22nd South Carolina player to reach 1,000 for his career.
Alabama cornerback and return man Javier Arenas was sidelined with an undisclosed injury.