Billy Ragone scored his second touchdown of the day on a 7-yard run with 25 seconds remaining and Pennsylvania edged Columbia 27-20 on Saturday.
The late score gave Penn its third straight win this season and kept Columbia winless in the series since 1996.
The Lions led 17-10 at halftime after Hamilton Garner scored on a 16-yard touchdown pass from Sean Brackett with 13:38 to play in the second quarter. After a 3-yard run by Brian Colavita early in the fourth gave Penn a 20-17 lead, Columbia tied it at 20-20 on a 35-yard field goal by Luke Eddy with 1:36 left in the game.
Penn (3-2, 2-0 Ivy League) got the game-winner on its next possession. Ragone ended with 185 yards passing and 39 yards rushing.
Sean Brackett passed for 218 yards and a touchdown for the Lions (0-5, 0-2), but was intercepted twice.