LeFevour completed 22-of-28 with one interception for Central Michigan (4-1, 2-0 Mid-American Conference). He threw an 11-yard touchdown to Bryan Anderson in the first quarter and a 27-yarder to Antonio Brown in the third.
The game was held up for 39 minutes while the crowd of 18,092 was evacuated with 5:48 left in the third quarter. Central Michigan was leading 20-10 after lightning was spotted around the stadium.
Ike Nduka, in his first career start for Buffalo (1-4, 0-2), rushed for 172 yards on 22 carries. Buffalo's Zach Maynard, who completed 16-of-31 with 210 yards and an interception, threw a 24-yard second-quarter touchdown to Naaman Roosevelt.
LeFevour broke Byron Leftwich's MAC record for career completions (939) in the first quarter.