Robert Nyakundi scored 18 points and SMU defeated UCF 65-43 in Conference USA play on Wednesday night.
Nyakundi scored 14 of his 18 points in the first half. Derek Williams added a double-double, with 12 points and 10 assists.
Keith Clanton was the only double-digit scorer for the Knights (10-10, 2-4) with 11.
The Mustangs (9-10, 2-3) jumped out to a 26-12 lead over the first 15:43 of the game and closed the half out on a 15-4 run to take a 41-16 lead into the half.
The Mustangs never let the Knights back in the game after halftime as they held at least a 22 point lead the entire second half.
The Mustangs now take a 3-2 advantage in the all-time series, with the home team having won every game.