Edwin Ubiles scored 19 points and led four Siena players in double figures in a 73-60 win over Iona on Monday night.
Alex Franklin scored 11 points and Clarence Jackson added 10 for the Saints (6-3) in their Metro Atlantic Athletic Conference opener.
Ryan Rossiter chipped in 15 points on 7-for-17 shooting for Siena, which shot 50 percent from the field (30 of 60).
The Saints trailed 11-7 early in the first half, before scoring 10 unanswered points for a 17-11 lead on two free throws by Franklin with 12:12 left in the half.
Siena shot 61.3 percent in the first half (19 of 31) and led 31-28 at halftime.
The Gaels (4-4, 0-2) pulled within 45-42 with 12:45 to play, but the Saints responded on a 24-8 run for a 69-50 lead with 3:46 left on an O.D. Anosike free throw.
Scott Machado scored nine points and grabbed five rebounds for Iona.